The Krische Research Group
Synthetic Methods & Natural Product Synthesis
 
 

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“Synthesis of seco-B-Ring Bryostatin Analogue WN-1 via C-C Bond Forming Hydrogenation: Critical Contribution of the B-Ring in Determining Bryostatin- and PMA-Like Properties,” Andrews, Ian P.; Ketcham, J. M.; Blumberg, P. M.; Kedei, N.; Lewin, N. E.; Krische, M. J. J. Am. Chem. Soc. 2014, 136, 13209.





“Polyketide Construction via Hydrohydroxyalkylation and Related Alcohol CH Functionalizations: Reinventing the Chemistry of Carbonyl Addition,” Dechert-Schmitt, A.-M. R.; Schmitt, D. C.; Gao, X.; Itoh, T.; Krische, M. J. Nat. Prod. Rep. 2014, 31, 504.




“Asymmetric Alcohol C-H Allylation and syn-Crotylation: C9-C20 of Tetrafibricin,” Itoh, T.; Montgomery, T. P.; Recio, A., III; Krische, M. J. Org. Lett. 2014, 16, 820.





“Total Synthesis of (+)-Trienomycins A and F via C-C Bond-Forming Hydrogenation and Transfer Hydrogenation,” Del Valle, D. J.; Krische, M. J. J. Am. Chem. Soc. 2013, 135, 10986.




“Total Synthesis of Cyanolide A in the Absence of Protecting Groups, Chiral Auxiliaries or Premetallated Carbon Nucleophiles,” Waldeck, A. R.; Krische, M. J. Angew. Chem. Int. Ed. 2013, 52, 4470.





“Total Synthesis of 6-Deoxyerythronolide B via C-C Bond-Forming Transfer Hydrogenation,” Gao, X.; Woo, S. K.; Krische, M. J. J. Am. Chem. Soc. 2013, 135, 4223.





“Total Synthesis of Bryostatin 7 via C-C Bond Forming Hydrogenation: Merged Redox-Construction Events for Synthetic Efficiency,” Lu, Y.; Woo, S. K.; Krische, M. J. J. Am. Chem. Soc. 2011, 133, 13876.




“C(21)-C(40) of Tetrafibricin via Metal Catalysis: Beyond Stoichiometric Chiral Reagents, Auxiliaries and Premetallated Nucleophiles,” Kumpulainen, E. T. T.; Kang, B.; Krische, M. J. Org. Lett. 2011, 13, 2484.






“Total Synthesis of (+)-Roxaticin via C-C Bond Forming Transfer Hydrogenation: A Departure from Stoichiometric Chiral Reagents, Auxiliaries and Premetallated Nucleophiles in Polyketide Construction,” Han, S. B.; Hassan, A.; Kim, I. S.; Krische, M. J. J. Am. Chem. Soc. 2010, 132, 15559.





“Synthesis of the Cytotrienin A Core via Metal Catalyzed C-C Coupling,” Rossle, M.; Del Valle, D. J.; Krische, M. J. Org. Lett. 2011, 13, 1482.





“Concise Synthesis of the Bryostatin A-Ring via Consecutive C-C Bond Forming Transfer Hydrogenations,” Lu, Y.; Krische, M. J. Org. Lett. 2009, 11, 3108.





"Asymmetric Total Synthesis of the Iridoid -Glucoside (+)-Geniposide via Phosphine Organocatalysis." Jones, R. A.; Krische, M. J. Org. Lett. 2009, 11, 1849.




“Enantioselective Reductive Coupling of Alkynes and -Ketoaldehydes via Rhodium-Catalyzed Hydrogenation: An Approach to Bryostatin Substructures,” Cho, C.-W.; Krische, M. J. Org. Lett. 2006, 8, 891.





“Intramolecular Organocatalytic [3+2] Dipolar Cycloaddition:  Stereospecific Cycloaddition and The Total Synthesis of (±)-Hirsutene,” Wang, J.-C.; Krische, M. J. Angew. Chem. Int. Ed. 2003, 42, 5855.





“Catalytic Crossed Michael Cycloisomerization of Thioenoates: Total Synthesis of ()-Ricciocarpin A,” Agapiou, K.; Krische, M. J. Org. Lett. 2003, 5, 1737.